Deciphering complicated pharmacology

Clyde has performed a number of mechanistic cardio vascular toxicity studies for pharma companies to decipher complicated pharmacology discovered during the in vivo testing.

Typically, a comprehensive analysis of cardiomyocyte function using a more chronic protocol can highlight the following mechanisms of toxicity;

  • Acute versus chronic effects

  • hERG trafficking

  • Chronotropic liability

  • Left ventricle dysfunction (negative inotropy)

  • Proarrhythmic risk

  • Mixed ion channel effects over time

  • Cytotoxicity (structural) though change in myocyte function


Typical Data – Pentamidine

Typical data from a Clyde Mechanistic Cardiovascular Toxicity Assay – Pentamidine

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