Defining an accurate pro arrhythmic risk of your compounds for IND submissions
Mechanistic CV Toxicity Assay
To better define the cardiovascular risk by measuring voltage, calcium and contractility to provide a comprehensive analysis of myocyte function during prolonged exposure of compound
hiPSC Cardiomyocyte Characterisation
& Validation Assay
Over the last 6 years Clyde has been instrumental in characterising hiPSC cardiomyocytes from all the major providers
Current assays may not have the sensitivity to detect changes in action potential upstroke. CellOPTIQ® is the only Voltage assay able to capture data fast enough to measure changes in upstroke directly.
Intracellular calcium transient measurements are critical for the understanding of cardiac function. Clyde’s CellOPTIQ® offers more accuracy and higher throughput than other assays.
Heart cell contractility is a sensitive indicator of toxic or therapeutic effects of drugs. CellOPTIQ® provides visual measurements of cells at high frequency providing a wealth of data for the assessment of potential contractility effects.
In Silico Modelling
In Silico modelling and screening will become a cornerstone of cardiotox testing in drug development. Clyde Biosciences’ In Silico service provides confidence about ion channel measurement of drug activity.